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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。    36岁的邓静2023年确诊为乳腺癌中晚期，她写下了100个人生遗愿清单，并拍下短视频，她表示，想给孩子留个念想。

二 | 　　据南风窗：邓静今年36岁，是一名乳腺癌晚期患者，经过6次化疗、乳房切除手术和25次放疗后，医生预计她的寿命只剩3-6个月。对一个癌症晚期的患者来说，没有什么比活着更困难，比死亡更简单的事情。放疗化疗的痛苦，除了患者本人，谁也不能感同身受。

三 | “吃也吃不下，睡也睡不着”，邓静觉得，自己每次治疗都是咬紧牙关过的。

四 | 　　在完成人生遗愿的过程中，邓静觉得，自己的心也在慢慢填满：挑战“陪孩子一天”时，邓静陪大儿子逛街，第一次没有要求地满足他所有心愿，但孩子只希望妈妈能像生病前一样，接自己放学；完成遗愿“给母亲的告白”时，邓静和母亲去西来寺祈福，第一次跟母亲讲起小时候不被偏爱的委屈；遗愿“给家人留下全家福”，是希望自己走后，能给他们留下永恒的回忆……　　（中国小康网综合@南风窗）。

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Published on:09:13:34